Radiotherapy is a safety critical and highly demanding treatment. From a patient perspective, it represents part of an incredibly emotional journey as it is typically associated with life changing conditions. Health care professionals (HCPs) working in radiotherapy have a challenging, multifaceted role. The emotional and physical needs of patients need to be carefully balanced alongside the requirements of efficiency placed on them by healthcare systems which are often under pressure. Current radiotherapy systems have evolved and been optimised over many years. Successive innovations have improved the accuracy of the treatment and reduced the likelihood and severity of complications. This iterative journey of improvement has been punctuated by a series of step-change innovations, most notably in imaging, that have impacted the type of treatments that are possible and the way that these are delivered.